dreadd agonist 21 Search Results


dreadd agonist 21 dihydrochloride  (Bio-Techne corporation)
99
Bio-Techne corporation dreadd agonist 21 dihydrochloride
Dreadd Agonist 21 Dihydrochloride, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dreadd+agonist+21/custom%406422%4036385662?v=Bio-Techne+corporation
Average 99 stars, based on 1 article reviews
dreadd agonist 21 dihydrochloride - by Bioz Stars, 2026-07
99/100 stars
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c21  (Tocris)
95
Tocris c21
Inhibition of interneuron activity in S1HL cortex results in hyperalgesia in older mice. (a) Representative immunostaining images. Brain slices throughout S1HL cortex were selected and stained with anti‐GABA receptor. Immunofluorescence imaging showed 80% dTomato+ cells were GABA+ cells in S1HL cortex. N = 4, data are represented as mean ± SD. (b) Diagram and sketch depict experiment design. AAV9‐Dlx‐Gi DREADD‐dTomato was injected into S1HL of adult mice. A representative image of brain slice with box region zoomed verified viral transfection in S1HL cortex. (c) Mechanical withdrawal threshold was significantly decreased after <t>C21</t> administrated. (d) Hindpaw withdrawal latency in response to S1HL inhibition. Comparing with the mice subject to vector virus, mice injected Gi GREADDs exhibited significant decreasing in hindpaw withdrawal latency after C21 administration. N = 8, data are presented as mean ± SD, two‐tailed paired t test, ** p < 0.01, NS: not significant ( p > 0.05).
C21, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dreadd+agonist+21/pmc11320346-151-0-1?v=Tocris
Average 95 stars, based on 1 article reviews
c21 - by Bioz Stars, 2026-07
95/100 stars
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dreadd agonist compound 21  (Tocris)
94
Tocris dreadd agonist compound 21
Inhibition of interneuron activity in S1HL cortex results in hyperalgesia in older mice. (a) Representative immunostaining images. Brain slices throughout S1HL cortex were selected and stained with anti‐GABA receptor. Immunofluorescence imaging showed 80% dTomato+ cells were GABA+ cells in S1HL cortex. N = 4, data are represented as mean ± SD. (b) Diagram and sketch depict experiment design. AAV9‐Dlx‐Gi DREADD‐dTomato was injected into S1HL of adult mice. A representative image of brain slice with box region zoomed verified viral transfection in S1HL cortex. (c) Mechanical withdrawal threshold was significantly decreased after <t>C21</t> administrated. (d) Hindpaw withdrawal latency in response to S1HL inhibition. Comparing with the mice subject to vector virus, mice injected Gi GREADDs exhibited significant decreasing in hindpaw withdrawal latency after C21 administration. N = 8, data are presented as mean ± SD, two‐tailed paired t test, ** p < 0.01, NS: not significant ( p > 0.05).
Dreadd Agonist Compound 21, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dreadd+agonist+21/bio_rxiv__2022__02__01__478652-141-9-16?v=Tocris
Average 94 stars, based on 1 article reviews
dreadd agonist compound 21 - by Bioz Stars, 2026-07
94/100 stars
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dreadd agonist 21  (MedChemExpress)
N/A
DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC50=1.7 nM).
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dreadd agonist 21  (Cayman Chemical)
N/A
DREADD Agonist 21
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dreadd agonist 21  (BOC Sciences)
N/A
DREADD agonist 21 has been found to be an agonist of hM3Dq with high selectivity.
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dreadd agonist 21 dihydrochloride  (Aladdin Scientific Corporation)
N/A
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dreadd agonist 21  (Selleck Chemicals)
N/A
DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (hM3Dq) with EC50 of 1.7 nM.
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dreadd agonist 21 dihydrochloride  (Biosynth Carbosynth)
N/A
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dreadd agonist 21  (Toronto Research Chemicals)
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Image Search Results


Inhibition of interneuron activity in S1HL cortex results in hyperalgesia in older mice. (a) Representative immunostaining images. Brain slices throughout S1HL cortex were selected and stained with anti‐GABA receptor. Immunofluorescence imaging showed 80% dTomato+ cells were GABA+ cells in S1HL cortex. N = 4, data are represented as mean ± SD. (b) Diagram and sketch depict experiment design. AAV9‐Dlx‐Gi DREADD‐dTomato was injected into S1HL of adult mice. A representative image of brain slice with box region zoomed verified viral transfection in S1HL cortex. (c) Mechanical withdrawal threshold was significantly decreased after C21 administrated. (d) Hindpaw withdrawal latency in response to S1HL inhibition. Comparing with the mice subject to vector virus, mice injected Gi GREADDs exhibited significant decreasing in hindpaw withdrawal latency after C21 administration. N = 8, data are presented as mean ± SD, two‐tailed paired t test, ** p < 0.01, NS: not significant ( p > 0.05).

Journal: Aging Cell

Article Title: Aging‐associated decrease of PGC ‐1α promotes pain chronification

doi: 10.1111/acel.14177

Figure Lengend Snippet: Inhibition of interneuron activity in S1HL cortex results in hyperalgesia in older mice. (a) Representative immunostaining images. Brain slices throughout S1HL cortex were selected and stained with anti‐GABA receptor. Immunofluorescence imaging showed 80% dTomato+ cells were GABA+ cells in S1HL cortex. N = 4, data are represented as mean ± SD. (b) Diagram and sketch depict experiment design. AAV9‐Dlx‐Gi DREADD‐dTomato was injected into S1HL of adult mice. A representative image of brain slice with box region zoomed verified viral transfection in S1HL cortex. (c) Mechanical withdrawal threshold was significantly decreased after C21 administrated. (d) Hindpaw withdrawal latency in response to S1HL inhibition. Comparing with the mice subject to vector virus, mice injected Gi GREADDs exhibited significant decreasing in hindpaw withdrawal latency after C21 administration. N = 8, data are presented as mean ± SD, two‐tailed paired t test, ** p < 0.01, NS: not significant ( p > 0.05).

Article Snippet: C21 (Tocris, catalog 5548) was intraperitoneally administered at 1 mg/kg.

Techniques: Inhibition, Activity Assay, Immunostaining, Staining, Immunofluorescence, Imaging, Injection, Slice Preparation, Transfection, Plasmid Preparation, Virus, Two Tailed Test

Activation of interneurons in S1HL alleviates aging‐associated pain chronification. (a) Diagram and sketch depict experimental design. AAV9‐Dlx‐Gq DREADD‐dTomato was injected into S1HL of adult mice. Following baseline behavioral test, mice received CCI surgery and C21 was administrated at day 14 after surgery. Pain behaviors were assessed 30 min after C21. (b) Mechanical withdrawal threshold. N = 8 mice, in mice received vector virus, before versus after surgery *** p < 0.001, before versus after C21 *** p < 0.001; in mice received Gq DREADD, before versus after surgery *** p < 0.001, before versus after C21 ** p < 0.01. (c) Hindpaw withdrawal latency. Comparing with mice subjected to vector virus, mice received Gq DREADD injection in S1HL and C21 administration exhibited significant increasing in mechanical withdrawal threshold and hindpaw withdrawal latency. N = 8, data are presented as mean ± SD in panel B. One‐way ANOVA followed by Tukey post hoc test was performed for the comparison. ** p < 0.01, *** p < 0.001. NS: not significant ( p > 0.05). (d) Representative immunofluorescent images. Brain slices throughout S1HL cortex were selected and stained with anti‐GABA. Immunofluorescence imaging showed 80% dTomato+ cells were GABA + cells in S1HL cortex. N = 4, data are represented as mean ± SD.

Journal: Aging Cell

Article Title: Aging‐associated decrease of PGC ‐1α promotes pain chronification

doi: 10.1111/acel.14177

Figure Lengend Snippet: Activation of interneurons in S1HL alleviates aging‐associated pain chronification. (a) Diagram and sketch depict experimental design. AAV9‐Dlx‐Gq DREADD‐dTomato was injected into S1HL of adult mice. Following baseline behavioral test, mice received CCI surgery and C21 was administrated at day 14 after surgery. Pain behaviors were assessed 30 min after C21. (b) Mechanical withdrawal threshold. N = 8 mice, in mice received vector virus, before versus after surgery *** p < 0.001, before versus after C21 *** p < 0.001; in mice received Gq DREADD, before versus after surgery *** p < 0.001, before versus after C21 ** p < 0.01. (c) Hindpaw withdrawal latency. Comparing with mice subjected to vector virus, mice received Gq DREADD injection in S1HL and C21 administration exhibited significant increasing in mechanical withdrawal threshold and hindpaw withdrawal latency. N = 8, data are presented as mean ± SD in panel B. One‐way ANOVA followed by Tukey post hoc test was performed for the comparison. ** p < 0.01, *** p < 0.001. NS: not significant ( p > 0.05). (d) Representative immunofluorescent images. Brain slices throughout S1HL cortex were selected and stained with anti‐GABA. Immunofluorescence imaging showed 80% dTomato+ cells were GABA + cells in S1HL cortex. N = 4, data are represented as mean ± SD.

Article Snippet: C21 (Tocris, catalog 5548) was intraperitoneally administered at 1 mg/kg.

Techniques: Activation Assay, Injection, Plasmid Preparation, Virus, Comparison, Staining, Immunofluorescence, Imaging